Reaktion #799363

Reaktionsgleichung

1-Ethyl-3-(6-methoxy-1,3-benzothiazol-2-yl)urea

Bromine

→

desired compound

1-(5-Bromo-6-methoxy-1,3-benzothiazol-2-yl)-3-ethyl-urea

Lösungsmittel

MeOH

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred for a total of 1.5 h
2. 2
   Einengenthen concentrated to dryness under reduced pressure

Vorschrift

1-Ethyl-3-(6-methoxy-1,3-benzothiazol-2-yl)urea (1.10 g, 4.38 mmol) was suspended in DCM (50 mL) and MeOH (5 mL). Bromine (0.34 mL, 6.60 mmol) was added and the mixture stirred at rt. The mixture was stirred for a total of 1.5 h then concentrated to dryness under reduced pressure. The desired compound was obtained as an orange solid, 2.17 g, and used without further purification, stating purity as 66 mass % in further reactions. m/z: 329.94/331.91 [M+H]+.

Quelle