Reaktion #7990

Reaktionsgleichung

HCl

Aluminum chloride

1-chloro-3-fluoro-2-methoxybenzene

hexanoyl chloride

→

1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture warmed
2. 2
   Sonstigepartitioned between EtOAc (40 mL) and ice cold water (40 mL)
3. 3
   WaschenThe EtOAc layer was washed with brine (30 mL)
4. 4
   Trocknendried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated under vacuum

Vorschrift

Aluminum chloride (1.16 g, 8.72 mmol) was added to a stirred mixture of 1-chloro-3-fluoro-2-methoxybenzene (1.00 mL, 8.72 mmol) and hexanoyl chloride (1.47 mL, 10.46 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 67 hours and then partitioned between EtOAc (40 mL) and ice cold water (40 mL). The EtOAc layer was washed with brine (30 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone as an oil.

Quelle