Reaktion #798732

Reaktionsgleichung

methyl 6-chloro-4-cyano-2-(1-methyl-1H-pyrazol-4-yl)nicotinate

(R)-tert-butyl 1-amino-3-methoxypropan-2-ylcarbamate

DIPEA

→

title compound

(R)-Methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(1-methyl-1H-pyrazol-4-yl)nicotinate

Lösungsmittel

EtOAc

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat 50° C. for 6 h
2. 2
   Waschenwas washed with water (10 mL) and brine (20 mL)
3. 3
   SonstigeThe organic layer was collected
4. 4
   Trocknendried over Na2SO4
5. 5
   Einengenwas concentrated to a yellow oil
6. 6
   SonstigeThe concentrate was purified via standard phase column chromatography
7. 7
   Wascheneluting with EtOAc and hexanes (50-100% EtOAc gradient)

Vorschrift

To a screw-top vial was added methyl 6-chloro-4-cyano-2-(1-methyl-1H-pyrazol-4-yl)nicotinate (115 mg, 0.416 mmol), (R)-tert-butyl 1-amino-3-methoxypropan-2-ylcarbamate (93 mg, 0.457 mmol), and DIPEA (87 μL, 0.499 mmol) in DMF (308 μL). The resulting yellow solution was stirred for 12 h at 45° C. and then at 50° C. for 6 h. The reaction mixture was diluted with EtOAc (20 mL) and was washed with water (10 mL) and brine (20 mL). The organic layer was collected and dried over Na2SO4 and was concentrated to a yellow oil. The concentrate was purified via standard phase column chromatography eluting with EtOAc and hexanes (50-100% EtOAc gradient) to give the title compound as a light yellow residue (36.5 mg, 20%). [M+H] calc'd for C21H28N6O5, 445. found, 445.

Quelle