Reaktion #798676

Reaktionsgleichung

ethyl 4-(1,5-dimethyl-1H-pyrazol-4-yl)-6-methyl-2-(methylsulfonyl)pyrimidine-5-carboxylate

tert-butyl (1S,2R)-2-aminocyclohexylcarbamate

Et3N

→

title compound

Ethyl 2-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-6-methylpyrimidine-5-carboxylate

Lösungsmittel

DMA

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThe reaction mixture was poured slowly onto ice
2. 2
   Sonstigeto yield a pale yellow precipitate
3. 3
   Sonstigewhich was isolated by vacuum filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried under vacuum

Vorschrift

A solution of ethyl 4-(1,5-dimethyl-1H-pyrazol-4-yl)-6-methyl-2-(methylsulfonyl)pyrimidine-5-carboxylate (0.07 g, 0.207 mmol), tert-butyl (1S,2R)-2-aminocyclohexylcarbamate (0.089 g, 0.414 mmol) and Et3N (0.115 mL, 0.827 mmol) in DMA (3 mL) was heated in a sealed tube at 90° C. for 8 h. The reaction mixture was poured slowly onto ice to yield a pale yellow precipitate, which was isolated by vacuum filtration, washed with water, and dried under vacuum to give the title compound. [M+H] calc'd for C24H36N6O4, 473. found, 473.

Quelle