Reaktion #79862

Reaktionsgleichung

trans-5-(3-methoxy-4-phenoxyphenyl)-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine acetate

trans-4-{4-chloro-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylphenyl phenyl ether

Hypersil

→

title compound

Ausbeute 75.0%

trans-5-(3-Methyl-4-phenoxyphenyl)-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Ausbeute 75.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigetr 15.93 min.

Vorschrift

The title compound was prepared in a 75% yield from trans-4-{4-chloro-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylphenyl phenyl ether in a similar manner to that described for the preparation of trans-5-(3-methoxy-4-phenoxyphenyl)-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine acetate: 1H NMR (DMSO-d6, 400 MHz) δ 8.13(s, 1H), 7.42(m, 4H), 7.37(t, 2H), 7.27(m, 1H), 7.10 (t, 1H), 6.97(m, 3H), 6.11(bs, 2H), 4.55(m, 1H), 2.2-2.6(m, 9H), 2.22(s, 3H), 2.14 (s, 3H), 1.7-2.0(m, 6H), 1.45(m, 2H); MS MH+497.4; RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 5%-100% acetonitrile—0.05 M ammonium acetate over 25 min, 1 ml/min) tr 15.93 min.

Quelle