Reaktion #79861

Reaktionsgleichung

Hypersil

trans-4-chloro-5-iodo-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidine

2-methyl-4-(4,4,5,5-tetrametyl-1,3,2-dioxaborolan-2-yl)phenyl phenyl ether

trans-5-(4-chloro-7-(4-(4-methylpiperazino)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-phenoxybenzonitrile

→

title compound

Ausbeute 82.0%

trans-4-{4-Chloro-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylphenyl Phenyl Ether

Ausbeute 82.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigetr 10.53 min.

Vorschrift

The title compound was prepared in an 82% yield from from trans-4-chloro-5-iodo-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidine and 2-methyl-4-(4,4,5,5-tetrametyl-1,3,2-dioxaborolan-2-yl)phenyl phenyl ether in similar manner to that described for the preparation of trans-5-(4-chloro-7-(4-(4-methylpiperazino)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-phenoxybenzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 8.65 (s, 1H), 7.98(s, 1H), 7.49 (s, 1H), 7.37(m, 3H), 7.10(t, 1H), 6.95(m, 3H), 4.72(m, 1H), 2.2-2.6(m, 9H), 2.23(s, 3H), 2.17(s, 3H), 2.01(m, 6H), 1.48 (m, 2H); MS MH+516.4; RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 10.53 min.

Quelle