Reaktion #798378

Reaktionsgleichung

Intermediate 74c

4-Iodo-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazole-3-carboxylic acid ethyl ester

lithium borohydride

→

title compound

Ausbeute 62.5%

{4-Iodo-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-3-yl}-methanol

Ausbeute 62.5%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITthen stood at RT overnight
2. 2
   workup.STIRRINGThe mixture was stirred at 60° C. for a further 5 h
3. 3
   Sonstigethen cautiously quenched with water
4. 4
   workup.ADDITIONdiluted with EtOAc and water
5. 5
   SonstigeThe phases were separated
6. 6
   Extraktionthe aqueous layer was extracted with EtOAc (2×)
7. 7
   WaschenThe combined organic layers were washed with saturated aqueous sodium bicarbonate solution and brine
8. 8
   Trocknendried (Na2SO4)
9. 9
   Filtrationfiltered
10. 10
    Sonstigeevaporated in vacuo
11. 11
    SonstigeThe residue was purified by FCC

Vorschrift

A solution of Intermediate 74c (1.22 g, 3.09 mmol) in dry THF (12 mL) was treated with lithium borohydride (0.10 g, 4.64 mmol) and the mixture was stirred at 60° C. for 5 h then stood at RT overnight. The mixture was stirred at 60° C. for a further 5 h then cautiously quenched with water and diluted with EtOAc and water. The phases were separated and the aqueous layer was extracted with EtOAc (2×). The combined organic layers were washed with saturated aqueous sodium bicarbonate solution and brine, dried (Na2SO4), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-100% EtOAc in cyclohexane, to give the title compound as a colorless oil (0.68 g, 62%). LCMS (Method 3): Rt 2.89 min, m/z 375 [M+Na+].

Quelle