Reaktion #798333

Reaktionsgleichung

3-bromo-5-fluorophenol

3-tert-butyl-1H-pyrazole-5-amine

potassium carbonate

→

title compound

Ausbeute 37.4%

3-(5-Amino-3-tert-butyl-pyrazol-1-yl)-5-fluoro-phenol

Ausbeute 37.4%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeDegassed toluene (sparged with argon for 25 mins, 10.0 mL)
2. 2
   Sonstigemicrowave irradiation
3. 3
   SonstigeThe mixture was partitioned between EtOAc and water
4. 4
   ExtraktionThe aqueous layer was then extracted with EtOAc (3×)
5. 5
   WaschenThe combined organic layers were washed with brine
6. 6
   Trocknendried (MgSO4)
7. 7
   Filtrationfiltered
8. 8
   Sonstigeevaporated in vacuo
9. 9
   SonstigeThe residue was purified by FCC

Vorschrift

Degassed toluene (sparged with argon for 25 mins, 10.0 mL) was added to a mixture of 3-bromo-5-fluorophenol (1.00 g, 5.23 mmol), 3-tert-butyl-1H-pyrazole-5-amine (728 mg, 5.23 mmol), copper (I) iodide (50.0 mg, 0.26 mmol) and potassium carbonate (1.52 g, 11.0 mmol). Trans-N,N′-dimethylcyclohexanediamine (165 μL, 1.05 mmol) was added and the reaction heated to 150° C. for 3.5 h using microwave irradiation. The mixture was partitioned between EtOAc and water. The aqueous layer was then extracted with EtOAc (3×). The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-75% EtOAc in cyclohexane, to give the title compound (488 mg, 37%). LCMS (Method 4): Rt 2.49 min, m/z 250 [MH+].

Quelle