Reaktion #798075

ord-9381e9fa4ee643e191f94ac7e4a79c1c

Reaktionsgleichung

Cc1ccc2[nH]c3c(c2c1)CN(C)CC3
2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole
C=C(C)c1ccc(C)nc1
2-methyl-5-(prop-1-en-2-yl)pyridine
[K+].[OH-]
KOH
→
Cc1ccc2c(c1)c1c(n2CC(C)c2ccc(C)nc2)CCN(C)C1
title compound
Cc1ccc2c(c1)c1c(n2CC(C)c2ccc(C)nc2)CCN(C)C1
2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)propyl)-1H-pyrido[4,3-b]indole

Edukte

Cc1ccc2[nH]c3c(c2c1)CN(C)CC3
2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole
C=C(C)c1ccc(C)nc1
2-methyl-5-(prop-1-en-2-yl)pyridine
[K+].[OH-]
KOH

Reagenzien

Keine

Lösungsmittel

CN1CCCC1=O
NMP

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeranging between 25 deg C
  2. 2
    Sonstigeto 100 deg C
  3. 3
    SonstigeThe product obtained
  4. 4
    Sonstigeis isolated by preparative HPLC

Vorschrift

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, 2-methyl-5-(prop-1-en-2-yl)pyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09181240B2uspto-grants-2015_11