Reaktion #79788

Reaktionsgleichung

3-Mesyloxy-8-methyl-8-azabicyclo[3.2.1 ]octane

Sodium hydride

5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

→

3-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-8-methyl-8-azabicyclo[3.2.1]octane

Lösungsmittel

dimethylformamide

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed under reduced pressure
2. 2
   workup.ADDITIONWater was added to the residue
3. 3
   Extraktionthe mixture was extracted with ethyl acetate
4. 4
   Sonstigeto give a residue which
5. 5
   Sonstigewas purified by flash column chromatography on silica
6. 6
   Sonstigeto remove
7. 7
   workup.ADDITIONa mixture of ethyl acetate/methanol/triethylamine (5:5:1) as the mobile phase
8. 8
   Waschento elute the product
9. 9
   Sonstigeevaporated
10. 10
    Sonstigeto give a solid which
11. 11
    Sonstigewas triturated with ether
12. 12
    Filtrationfiltered

Vorschrift

Sodium hydride (168 mg, of a 60% dispersion in mineral oil) was added to a mixture of 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (770 mg, in dimethylformamide (30 ml). 3-Mesyloxy-8-methyl-8-azabicyclo[3.2.1 ]octane (900 mg, prepared as described in J.A.C.S. 1958, 80, 4679) in dimethylformamide (10 ml) was added under nitrogen with stirring. The mixture was warmed at 75° C. for 5 hours (and left standing at ambient temperature for 7 days). The solvent was removed under reduced pressure. Water was added to the residue and the mixture was extracted with ethyl acetate to give a residue which was purified by flash column chromatography on silica using ethyl acetate/methanol (50:50) as the mobile phase to remove starting material and then a mixture of ethyl acetate/methanol/triethylamine (5:5:1) as the mobile phase to elute the product. Appropriate fractions were combined and evaporated to give a solid which was triturated with ether and filtered to give 3-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-8-methyl-8-azabicyclo[3.2.1]octane, m.p. 238-250° C.

Quelle