Reaktion #79777

Reaktionsgleichung

4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine

sodium hydride

Ethyl bromoacetate

→

ethyl 2-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetate

Lösungsmittel

dimethylformamide

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred for 30 minutes at ambient temperature
2. 2
   SonstigeThe mixture was evaporated under vacuum
3. 3
   Sonstigethe residue was triturated with water and ether
4. 4
   SonstigeThe solid obtained
5. 5
   Filtrationwas collected by filtration
6. 6
   Waschenwashed with water

Vorschrift

A mixture of 4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (906 mg), sodium hydride (120 mg, of a 60% dispersion in mineral oil) and dry dimethylformamide (30 ml) was stirred at ambient temperature under nitrogen for 30 minutes. Ethyl bromoacetate (0.5 g) in dimethylformamide (10 ml) was added over 5 minutes at 0-5° C. with stirring. The mixture was stirred for 30 minutes at ambient temperature and then allowed to stand for 18 hours. The mixture was evaporated under vacuum and the residue was triturated with water and ether. The solid obtained was collected by filtration, washed with water and then with ether to give ethyl 2-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetate, m.p. 161-161.3° C.

Quelle