Reaktion #797654
ord-2abe0e9771bf47f3b6e4f093ccec56c1
Reaktionsgleichung
6-iodonicotinic acid
3-iodo-4-propylbenzoic acid
→
title compound
Ausbeute 45.0%
6-(Prop-1-ynyl)nicotinic acid
Ausbeute 45.0%
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
When 6-iodonicotinic acid was substituted for the 3-iodo-4-propylbenzoic acid in Example 47, Step B, the similar process afforded the title compound in 45% yield, as yellow solid. 1H-NMR (CDCl3) 2.12 (s, 3H); 7.25 (broad s, 1H+H2O); 7.46 (dd, 1H, J=0.6, 7.6 Hz); 8.2 (dd, 1H, J=2.16, 6 Hz); 9.23 (dd, 1H, J=0.8, 1.4 Hz).