Reaktion #797

Reaktionsgleichung

COc1cc(Cl)ccc1I

CN1CCNCC1

→

COc1cc(Cl)ccc1N1CCN(

Lösungsmittel

Cc1ccccc1

Reaktionsbedingungen

Vorschrift

1-methylpiperazine (0.021 mL, 0.19 mmol) was added to 4-chloro-1-iodo-2-methoxybenzene (50 mg, 0.19 mmol) and sodium 2-methylpropan-2-olate (35.8 mg, 0.37 mmol) in toluene (0.650 mL) and the solution degassed. rac-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (11.60 mg, 0.02 mmol) and Palladium II acetate (4.18 mg, 0.02 mmol) were added to the resulting mixture and the vial stirred at 80 °C for 17 hours. LCMS revelead product peak, but not great. Product not isolated.

Quelle