Reaktion #796791

Reaktionsgleichung

ethyl 3-cyclopropyl-3-(6-methoxypyrimidin-4-yl)acrylate

→

title compound

Ausbeute 101.2%

ethyl 3-cyclopropyl-3-(6-methoxypyrimidin-4-yl)propanoate

Ausbeute 101.2%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   Sonstigethe solvent in the filtrate was evaporated under reduced pressure

Vorschrift

A zinc powder (11.5 g) was added to a solution of ethyl 3-cyclopropyl-3-(6-methoxypyrimidin-4-yl)acrylate (5.57 g) in acetic acid (60 mL), and the mixture was stirred at room temperature for 10 min. The reaction mixture was filtered, and the solvent in the filtrate was evaporated under reduced pressure to give a crude product of the title compound (5.68 g) as a yellow oil. This compound was used for the next step without further purification.

Quelle