Reaktion #7963

Reaktionsgleichung

(2SR,9aRS)-9a-butyl-2-hydroxy-7-methoxymethoxy-4-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one

HCl

→

(2SR,9aRS)-9a-butyl-2,7-dihydroxy-4-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one

Lösungsmittel

EtOAc

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to room temperature
2. 2
   Waschenwashed with 5% aqueous NaHCO3 and brine
3. 3
   Trocknendried over MgSO4
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated under vacuum to an oil
6. 6
   SonstigeThe crude product was purified by PLC on a 0.1×20×20 cm silica gel GF plate
7. 7
   WaschenThe band at Rf 0.12-0.20 was eluted with EtOAc
8. 8
   Sonstigethe eluant evaporated under vacuum to a gum (50 mg)
9. 9
   SonstigeThis material crystallized from benzene

Vorschrift

A solution of (2SR,9aRS)-9a-butyl-2-hydroxy-7-methoxymethoxy-4-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one (73 mg, 0.22 mmol) in methanol (5 mL) was placed under a nitrogen atmosphere, treated with 2N aqueous HCl (0.33 mL, 0.66 mmol), and stirred with heating in an oil bath at 80° C. for 30 minutes. After cooling to room temperature, the reaction mixture was diluted with EtOAc, washed with 5% aqueous NaHCO3 and brine, dried over MgSO4, filtered, and concentrated under vacuum to an oil. The crude product was purified by PLC on a 0.1×20×20 cm silica gel GF plate, developing twice with 4:1 hexanes-EtOAc. The band at Rf 0.12-0.20 was eluted with EtOAc and the eluant evaporated under vacuum to a gum (50 mg). This material crystallized from benzene to afford (2SR,9aRS)-9a-butyl-2,7-dihydroxy-4-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one as a white solid.

Quelle