Reaktion #79589

Reaktionsgleichung

product

9-benzyl-5,7-dimethoxy-1,2,3,4-tetrahydrocarbazole-4-carboxamide

→

subtitled product

9-benzyl-4-carbamoyl-5,7-dimethoxycarbazole

Lösungsmittel

carbitol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 2.0 gm
2. 2
   Filtrationfiltered while still hot, and the solid
3. 3
   Waschenwashed well with ethyl acetate
4. 4
   WaschenThe combined filtrates were washed with water
5. 5
   Waschenwashed with brine
6. 6
   Trocknendried over sodium sulfate
7. 7
   Sonstigeevaporated in vacuo

Vorschrift

A mixture of 2.0 gm. of the product from Example 2, 2 gm. of 5% Pd/C, and 100 mL of carbitol was refluxed for 17 hours,filtered while still hot, and the solid washed well with ethyl acetate. The combined filtrates were washed with water, washed with brine, dried over sodium sulfate, and evaporated in vacuo to give subtitled product, 1.4 gm., 70%, mp 240-243° C.

Quelle