Reaktion #79572

Reaktionsgleichung

methyl n-octanesulphonylacetate

ammonium hydroxide

→

acetamide

n-Octanesulphonylacetamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe white precipitate formed
2. 2
   Filtrationwas filtered
3. 3
   SonstigeThe solid was recrystallized from hot ethyl acetate

Vorschrift

A solution of methyl n-octanesulphonylacetate (35 g, 0.143 mole) in 350 ml of anhydrous methanol was stirred magnetically at room temperature. To this solution was added 24 ml of aqueous ammonium hydroxide (27%, 6.48 g, 0.185 mole) in drops over a period of 30 minutes. The solution was stirred for 24 h and the white precipitate formed was filtered. The solid was recrystallized from hot ethyl acetate to obtain the required acetamide III-50 as a crystalline solid, mp. 140-142° C., 33 g, 97.6%.

Quelle