Reaktion #795509

Reaktionsgleichung

2-bromo-N-(prop-2-yn-1-yl)acetamide

N-methyl piperazine

→

title compound

Ausbeute 49.0%

2-(4-methylpiperazin-1-yl)-N-(prop-2-yn-1-yl)acetamide

Ausbeute 49.0%

Lösungsmittel

DCM

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction mixture
2. 2
   Waschenwashed with water and brine
3. 3
   TrocknenThe organic layer was dried over Na2SO4
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe crude residue was triturated with ether-pentane

Vorschrift

To a solution of 2-bromo-N-(prop-2-yn-1-yl)acetamide (0.7 g, 3.98 mmol) in DCM (10 mL) added N-methyl piperazine (0.66 mL, 5.96 mmol) drop wise. Reaction mixture stirred at rt for 16 h, diluted with DCM and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude residue was triturated with ether-pentane, affording the title compound (0.38 g, 49%); LCMS: m/z=196.15 (M+1); 1H NMR (300 MHz, DMSO-d6) δ 8.06 (d, J=6.1 Hz, 1H), 3.86 (dd, J=5.9, 2.5 Hz, 2H), 3.07 (t, J=2.5 Hz, 1H), 2.91 (s, 2H), 2.47-2.25 (m, 8H), 2.15 (s, 3H).

Quelle