Reaktion #795508

Reaktionsgleichung

2-bromo-N-(prop-2-yn-1-yl)acetamide

trimethylamine

→

title compound

Ausbeute 97.0%

N,N,N-Trimethyl-2-oxo-2-(prop-2-yn-1-ylamino)ethanaminium bromide

Ausbeute 97.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   SonstigeThe resulting residue was triturated with ether

Vorschrift

To a solution of 2-bromo-N-(prop-2-yn-1-yl)acetamide (0.6 g, 3.4 mmol) in acetonitrile (5 mL) was added trimethylamine (30% in MeOH, 5 mL). The mixture was stirred at room temperature for 16 h and concentrated in vacuo. The resulting residue was triturated with ether, resulting in the title compound (780 mg, 97%); LCMS: m/z=155.1 (M+1); 1H NMR (300 MHz, DMSO-d6) δ 9.03 (t, J=5.3 Hz, 1H), 4.17 (s, 2H), 3.95 (dd, J=5.4, 2.6 Hz, 2H), 3.23 (s, 9H), 2.09 (s, 1H).

Quelle