Reaktion #795348

ord-5c69a58c257840859d1bcbf923c19648

Reaktionsgleichung

CC(C)(CNC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(N)=S
1-(2-methyl-1-(tritylamino)propan-2-yl)thiourea
O=C1c2ccc(Br)cc2OCCC1Br
4,8-dibromo-3,4-dihydro-2Hbenzo[b]oxepin-5-one
→
Br.CC(C)(CN)Nc1nc2c(s1)CCOc1cc(Br)ccc1-2
N2-(8-bromo-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-2-methylpropane-1,2-diamine hydrobromide
Ausbeute 68.0%

Edukte

CC(C)(CNC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(N)=S
1-(2-methyl-1-(tritylamino)propan-2-yl)thiourea
O=C1c2ccc(Br)cc2OCCC1Br
4,8-dibromo-3,4-dihydro-2Hbenzo[b]oxepin-5-one

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturunder reflux for 18 hours

Vorschrift

Following the Example 356, 1-(2-methyl-1-(tritylamino)propan-2-yl)thiourea was reacted with 4,8-dibromo-3,4-dihydro-2Hbenzo[b]oxepin-5-one in ethanol under reflux for 18 hours to give N2-(8-bromo-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-2-methylpropane-1,2-diamine hydrobromide. Yield 68%. MS(ESI+): 368.0

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09175009B2uspto-grants-2015_11