Reaktion #79422

Reaktionsgleichung

(4-Benzyloxy-phenyl)-(6-chloro-pyrido[3,4-d]pyrimidin-4-yl)-amine

3-(1,3-dioxolan-2-yl)-phenyl-tributylstannane

→

foam

Ausbeute 13.7%

(4-Benzyloxy-phenyl)-(6-(3-(1,3-dioxolan-2-yl)-phenyl)-pyrido[3,4-d]pyrimidin-4-yl)-amine

Ausbeute 13.7%

Lösungsmittel

dioxan

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated
2. 2
   FiltrationThis was then filtered through celite
3. 3
   Sonstigethe solvent evaporated
4. 4
   SonstigeThe gummy residue was then triturated with hexane giving a beige solid
5. 5
   SonstigeThis material was further purified by column chromatography

Vorschrift

(4-Benzyloxy-phenyl)-(6-chloro-pyrido[3,4-d]pyrimidin-4-yl)-amine (1.4 g) and 3-(1,3-dioxolan-2-yl)-phenyl-tributylstannane (3.08 g) [A. Lee and W-C. Dai, Tetrahedron (1997), 53(3), 859-868] in dioxan (30 ml) were reacted together as in Procedure B. The mixture was evaporated and the residue suspended in dichloromethane. This was then filtered through celite and the solvent evaporated. The gummy residue was then triturated with hexane giving a beige solid. This material was further purified by column chromatography, giving a brown foam (252 mg); m/z 477 (M+1)+.

Quelle