Reaktion #79393

ord-bfe24bfb8e9548ef81220f26e4b60b11

Reaktionsgleichung

Nc1ccc(S(=O)(=O)c2ccccc2)cc1
4-(benzenesulphonyl)phenylamine
Fc1cc2ncnc(Cl)c2cc1I
4-chloro-6-iodo-7-fluoroquinazoline
→
Cl.O=S(=O)(c1ccccc1)N(c1ccccc1)c1ncnc2cc(F)c(I)cc12
(4-Benzenesulphonyl)phenyl-(6-iodo-7-fluoro-quinazolin-4-yl)-amine hydrochloride

Edukte

Nc1ccc(S(=O)(=O)c2ccccc2)cc1
4-(benzenesulphonyl)phenylamine
Fc1cc2ncnc(Cl)c2cc1I
4-chloro-6-iodo-7-fluoroquinazoline

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to Procedure A from 4-(benzenesulphonyl)phenylamine and 4-chloro-6-iodo-7-fluoroquinazoline. 1H NMR (400 MHz, DMSO-d6) δ: 10.89(s, 1H), 9.3(d, 1H), 8.79(s, 1H), 8.07(d, 2H), 8.0(d, 2H), 7.94(d, 2H), 7.67(m, 2H), 7.61(m, 2H). ESI-MS m/z 504(M−1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06713485B2uspto-grants-2004_03