Reaktion #793514

Reaktionsgleichung

4-vinylbiphenyl

NaOH

5,5-dimethylimidazolidine-2,4-dione

(DHQ)2PHAL

4-iodobenzene-1,2-diamine

cesium fluoride

ethyl carbamate

cyclohexane-1,2-diamine

→

(S)-3-(1H-benzo[d]imidazol-6-yl)-4-(biphenyl-4-yl)oxazolidin-2-one

Lösungsmittel

triethyl orthoformate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe compound was synthesized

Vorschrift

The compound was synthesized starting from 4-vinylbiphenyl (1.55 g 8.6 mmol), ethyl carbamate (2.38 g, 26.7 mmol), 5,5-dimethylimidazolidine-2,4-dione (2.6 g, 13.2 mmol), (DHQ)2PHAL (0.402 g, 0.52 mmol), K2OsO4x2H2O (0.127 g, 0.34 mmol), 0.38 M aqueous NaOH (74 mL, 28 mmol), 4-iodobenzene-1,2-diamine (0.35 g, 1.5 mmol), copper(I) iodide (0.029 g, 0.15 mmol), cesium fluoride (0.456 g, 3 mmol), cyclohexane-1,2-diamine (0.018 mL, 0.15 mmol), triethyl orthoformate (10 ml) as described in method 5.

Quelle