Reaktion #792617

Reaktionsgleichung

4-(2-methylthiazol-4-yl)aniline

2,4-dichlorobenzoic acid

diisopropylethylamine

HATU

→

2,4-dichloro-N-(4-(2-methylthiazol-4-yl)phenyl)benzamide

Lösungsmittel

dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred for 20 minutes
2. 2
   FiltrationThe product (0.094 g, 100%) as a light yellow solid was collected via filtration

Vorschrift

To a solution of 4-(2-methylthiazol-4-yl)aniline (0.05 g, 0.26 mmol) and 2,4-dichlorobenzoic acid (0.05 g, 0.26 mmol) in dimethylformamide (20 mL) and diisopropylethylamine (0.067 g, 0.09 mL, 0.52 mmol) at room temperature was added HATU (0.148 g, 0.39 mmol) in one portion. The reaction was stirred at room temperature for 4 hours, then poured in to water (200 mL) and stirred for 20 minutes. The product (0.094 g, 100%) as a light yellow solid was collected via filtration. LC-MS (M+H): 364. 1H NMR (400 MHz, dmso-d6): 10.67 (s, 1H), 7.95 (d, 2H), 7.87 (s, 1H), 7.80-7.77 (m, 3H), 7.69-7.58 (m, 2H), 2.74 (s, 3H).

Quelle