Reaktion #791994

ord-78d9bb44a84c4f518989a8bd3e638527

Reaktionsgleichung

CC(C=Cc1cccc(Oc2ccccc2)c1)N(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C
product
CC(C=Cc1cccc(Oc2ccccc2)c1)N(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C
N,O-bis(t-butoxycarbonyl)-N-[1-methyl-3-(3-phenoxyphenyl)prop -2-en-1-yl]hydroxylamine
O=C(O)C(F)(F)F
trifluoroacetic acid
→
CC(=O)N(O)C(C)/C=C/c1cccc(Oc2ccccc2)c1
hydroxylamine
CC(=O)N(O)C(C)/C=C/c1cccc(Oc2ccccc2)c1
(+)-(E)-N-[1-methyl-3-(3-phenoxyphenyl)prop-2-enyl]acetohydroxamic acid

Edukte

CC(C=Cc1cccc(Oc2ccccc2)c1)N(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C
product
CC(C=Cc1cccc(Oc2ccccc2)c1)N(OC(=O)OC(C)(C)C)C(=O)OC(C)(C)C
N,O-bis(t-butoxycarbonyl)-N-[1-methyl-3-(3-phenoxyphenyl)prop -2-en-1-yl]hydroxylamine
O=C(O)C(F)(F)F
trifluoroacetic acid

Reagenzien

Keine

Lösungsmittel

ClCCl
methylene chloride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The product from step (e) (1.97 g) was taken up in methylene chloride (12 ml) and trifluoroacetic acid (3 ml) was added under N2. The mixture was stirred for 1 hour at room temperature and then stripped to give the hydroxylamine as a viscous tan/red oil which was taken up in methylene chloride (5 ml).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04988733uspto-grants-1991_01