Reaktion #79111

Reaktionsgleichung

2,6-Difluoropyridine

lithium diisopropylamide

CO2

→

2,6-difluoronicotinic acid

Ausbeute 97.0%

Lösungsmittel

cyclohexane

THF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with EtOAc
2. 2
   Extraktionextracted with EtOAc

Vorschrift

2,6-Difluoropyridine (7.89 mL, 0.087 mmol) is added dropwise under N2 at 78° C. to a stirred solution of lithium diisopropylamide (59.0 mL of a 1.5 N solution in cyclohexane, 0.089 mmol) in THF (250 mL). After 2 h at 78° C., a stream of dry CO2 is passed through the solution and the mixture is diluted with water and washed with EtOAc. The aqueous portion is neutralized with 3 N HCl, extracted with EtOAc and worked up to give 2,6-difluoronicotinic acid (13.4 g, 97%). H NMR (DMSO) δ 8.59 (1H, dd, J=9.2, 8.2 Hz), 7.30 (1H, dd, J=8.2, 2.1 Hz), 4.03 (1H, brs).

Quelle