Reaktion #79109

Reaktionsgleichung

2-Amino nicotinic acid

formamide

→

3H-pyrido[2,3-d]pyrimidin-4-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturUpon cooling a solid
2. 2
   Sonstigeprecipitates
3. 3
   FiltrationThe solid is filtered
4. 4
   Waschenwashed with H2O
5. 5
   Sonstigedried in a vacuum oven

Vorschrift

2-Amino nicotinic acid (15 g, 108.6 mmol) in formamide (35 mL) is heated to 165 −170° C. for 3.5 h. Upon cooling a solid precipitates. The solid is filtered and washed with H2O and dried in a vacuum oven to give 3H-pyrido[2,3-d]pyrimidin-4-one (7.87 g, 49.4). 1H NMR (DMSO) δ 12.50 (1H, s), 8.97 (1H, dd, J=1.9, 4.5 Hz), 8.53 (1H, dd, J=2.1, 7.9 Hz), 8.34 (1H, s), 7.57 (1H, dd, J=4.6, 8.0 Hz).

Quelle