Reaktion #790903

Reaktionsgleichung

nicotinoyl chloride

β-estradiol

→

title compound

Ausbeute 90.3%

3,17β-Bis[(3-pyridinylcarbonyl)oxy]estra-1,3,5(10)-triene

Ausbeute 90.3%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed for 1 hour
2. 2
   Filtrationthe resulting precipitate was collected by filtration
3. 3
   TrocknenThe precipitate was dried in vacuo over P2O5

Vorschrift

To 5.3 g (0.03 mo1) of nicotinoyl chloride in 30 mL of dry pyridine at 0° C. were added 2.0 g (0.0073 mol) of β-estradiol. The reaction mixture was refluxed for 1 hour, then was poured over 100 mL of ice water, and the resulting precipitate was collected by filtration. The precipitate was dried in vacuo over P2O5, affording 3.18 g (90%) of the title compound melting at 148°-150° C.

Quelle