Reaktion #790511

Reaktionsgleichung

1-(2-hydroxy-5-tetradecylphenyl)-1-hexanone

hydrochloric acid

water

→

desired compound

Ausbeute 41.1%

2-Hexyl-4-tetradecylphenol

Ausbeute 41.1%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Sonstigethe solvents removed
3. 3
   SonstigeThe residue was chromatographed on silica gel
4. 4
   Wascheneluting with hexane:ethyl acetate (40:1)

Vorschrift

A mixture of 31.04 g of 1-(2-hydroxy-5-tetradecylphenyl)-1-hexanone, 8.4 g of 5% palladium on carbon, 5 ml of concentrated hydrochloric acid, 95 ml of water and 100 ml of glacial acetic acid was hydrogenated in a Parr apparatus for 16 hours, then filtered and the solvents removed. The residue was chromatographed on silica gel, eluting with hexane:ethyl acetate (40:1), giving 12.3 g of the desired compound.

Quelle