Reaktion #79030

ord-055bc30b83a44a38a92b9a4d0890a857

Reaktionsgleichung

NS(=O)(=O)c1ccc(Br)s1
5-bromothiophene-2-sulphonamide
CC1(C)OC(=O)Nc2ccc(B(O)O)cc21
(1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid
CC1(C)OC(=O)Nc2ccc(-c3ccc(S(N)(=O)=O)s3)cc21
5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]-oxazin-6-yl)-thiophene-2-sulfonamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to procedure B from 5-bromothiophene-2-sulphonamide and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. White solid: mp 258-260° C.; 1H-NMR (DMSO-d6) δ 10.41 (s, 1H), 7.71 (s, 2H), 7.58 (m, 2H), 7.52 (d, 1H, J=3.9 Hz), 7.48 (d, 1H, J=8.16 Hz), 6.95 (d, 1H, J=8.16 Hz), 1.66 (s, 6H); MS m/z 337 (M−H). Anal. Calc. for C14H14N2O4S2: C, 49.69; H, 4.17; N, 8.28. Found: C, 49.90; H, 4.28; N, 8.12.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06713478B2uspto-grants-2004_03