Reaktion #78890

Reaktionsgleichung

7-ethoxytetrahydrocarbazole-6-carboxylic acid

toluene

chloranil

→

9-ethyl-5-ethoxycarbazole-6-carboxylic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 2 hours and 30 minutes
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Einengenthe filtrate was concentrated under reduced pressure
4. 4
   Sonstigepurified by silica gel column chromatography (ethyl acetate)

Vorschrift

The 7-ethoxytetrahydrocarbazole-6-carboxylic acid obtained in Example 37 was dissolved in 8 mL of toluene, and the solution was added with 2.14 g of chloranil and refluxed for 2 hours and 30 minutes. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (ethyl acetate) to obtain 336 mg of 9-ethyl-5-ethoxycarbazole-6-carboxylic acid. Compound 1-38 was obtained in the same manner as in Example 36 except that the 9-ethyl-5-ethoxycarbazole-6-carboxylic acid obtained was used.

Quelle