Reaktion #78701

ord-4f3e7b524e7a4efd8740ba95e350fbbf

Reaktionsgleichung

Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-n3c(C(C)C)nc4c(C)cc(C)nc43)cc2)cc1
2-{4-[(3-amino-5-bromo-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethanol
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-n3c(C(C)C)nc4c(C)cc(C)nc43)cc2)cc1
2-ISOPROPYL-5,7-DIMETHYL-3-(4-{2-[({[(4-METHYLPHENYL)SULFONYL]AMINO}CARBONYL)AMINO]ETHYL}PHENYL)-3H-IMIDAZO[4,5-b]PYRIDINE
CCCCC(=O)Cl
pentanoyl chloride
→
CCCCc1nc2c(C)cc(C)nc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
title compound
CCCCc1nc2c(C)cc(C)nc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
2-BUTYL-5,7-DIMETHYL-3-(4-{2-[({[(4-METHYLPHENYL)SULFONYL]AMINO}CARBONYL)AMINO]ETHYL}PHENYL)-3H-IMIDAZO[4,5-b]PYRIDINE

Edukte

Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-n3c(C(C)C)nc4c(C)cc(C)nc43)cc2)cc1
2-{4-[(3-amino-5-bromo-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethanol
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-n3c(C(C)C)nc4c(C)cc(C)nc43)cc2)cc1
2-ISOPROPYL-5,7-DIMETHYL-3-(4-{2-[({[(4-METHYLPHENYL)SULFONYL]AMINO}CARBONYL)AMINO]ETHYL}PHENYL)-3H-IMIDAZO[4,5-b]PYRIDINE
CCCCC(=O)Cl
pentanoyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared according to the procedure described in step 5 of Example 1 from 2-{4-[(3-amino-5-bromo-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethanol (step 4 of Example 9) and pentanoyl chloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06710054B2uspto-grants-2004_03