Reaktion #78494

ord-90517ebecf1c44bdbe3f3b467df05aa3

Reaktionsgleichung

CNc1ccc(C#N)cc1
4-cyano-N-methylaniline
CCOC(=O)CCN(C(=O)c1ccc2sc(COC)nc2c1)c1ccccc1
2-methoxymethylbenzothiazole-5-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
→
CCOC(=O)CCN(C(=O)c1ccc2sc(CN(C)c3ccc(C#N)cc3)nc2c1)c1ccccc1
2-[N-(4-Cyanophenyl)-N-methylaminomethyl]benzothiazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
Ausbeute 57.0%

Edukte

CNc1ccc(C#N)cc1
4-cyano-N-methylaniline
CCOC(=O)CCN(C(=O)c1ccc2sc(COC)nc2c1)c1ccccc1
2-methoxymethylbenzothiazole-5-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide

Reagenzien

Keine

Lösungsmittel

CCO.ClCCl
dichloromethane ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 9e from 4-cyano-N-methylaniline and 2-methoxymethylbenzothiazole-5-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide. Yield: 57% of theory; Rf value: 0.46 (silica gel; dichloromethane/ethanol=19:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06710055B2uspto-grants-2004_03