Reaktion #78468

Reaktionsgleichung

methyl 6-methylamino-5-nitronicotinate

hydrogen

ethyl acetate ethanol ammonia

→

Methyl 5-amino-6-methylaminonicotinate

Lösungsmittel

ethanol dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was then filtered off
2. 2
   workup.DISTILLATIONthe solvent was distilled off in vacuo
3. 3
   SonstigeThe crude oily product obtained
4. 4
   Sonstigewas further reacted directly

Vorschrift

To a solution of 3.1 g (15 mmol) of methyl 6-methylamino-5-nitronicotinate in 100 mL of ethanol/dichloromethane (3:1) was added 1 g of palladium on charcoal (10%) and the resulting suspension was hydrogenated at room temperature under 5 bar of hydrogen pressure for 1.5 hours. The catalyst was then filtered off and the solvent was distilled off in vacuo. The crude oily product obtained was further reacted directly. Yield: 2.4 g (92% of theory); Rf value: 0.44 (silica gel; ethyl acetate/ethanol/ammonia=90:10:1).

Quelle