Reaktion #78373

Reaktionsgleichung

3-(1-Thyminyl)-propanoic acid methyl ester

hydrochloric acid

→

title compound

Ausbeute 71.0%

3-(1-Thyminyl)-propanoic Acid

Ausbeute 71.0%

Lösungsmittel

sodium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe solution was extracted with ethyl acetate (10×25 ml)
2. 2
   ExtraktionThe organic phase was extracted with saturated aqueous sodium chloride
3. 3
   Trocknendried over magnesium sulfate
4. 4
   Sonstigeevaporated to dryness, in vacuo

Vorschrift

3-(1-Thyminyl)-propanoic acid methyl ester (1.0 g, 0.0047 mol) was suspended in 2 M sodium hydroxide (15 ml), boiled for 10 min. The pH was adjusted to 0.3 with conc. hydrochloric acid. The solution was extracted with ethyl acetate (10×25 ml). The organic phase was extracted with saturated aqueous sodium chloride, dried over magnesium sulfate, and evaporated to dryness, in vacuo, to give the title compound as a white solid (0.66 g, 71%). M.p. 118-121° C. Anal. for C8H10N2O4, found (calc.) C, 48.38 (48.49) H, 5.09 (5.09); N, 13.93 (14.14). The compound showed satisfactory 1H and 13C-NMR spectra.

Quelle