Reaktion #78369

Reaktionsgleichung

hydrochloric acid

2-amino-6-chloropurine

potassium carbonate

bromoacetic acid

→

2-Amino-6-chloro-9-carboxymethylpurine

Lösungsmittel

DMF

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe solution was filtered through Celite
2. 2
   Sonstigeto give a clear yellow solution
3. 3
   FiltrationThe precipitate was filtered
4. 4
   Sonstigedried, in vacuo
5. 5
   SonstigeYield (3.02 g; 44.8%)

Vorschrift

To a suspension of 2-amino-6-chloropurine (5.02 g; 29.6 mmol) and potassium carbonate (12.91 g; 93.5 mmol) in DMF (50 ml) was added bromoacetic acid (4.70 g; 22.8 mmol). The mixture was stirred vigorously for 20 h. under nitrogen. Water (150 ml) was added and the solution was filtered through Celite to give a clear yellow solution. The solution was acidified to a pH of 3 with 4 N hydrochloric acid. The precipitate was filtered and dried, in vacuo, over sicapent. Yield (3.02 g; 44.8%). 1H-NMR(DMSO-d6): d=4.88 ppm (s,2H); 6.95 (s,2H); 8.10 (s,1H).

Quelle