Reaktion #78219

Reaktionsgleichung

ethyl nipecotate

4-chloropyridine hydrochloride

triethylamine

xylene

→

title compound

Ethyl 1-(4-Pyridyl)-piperidine-3-carboxylate

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe obtained residue was purified by the silica gel chromatography (ethyl acetate/ethanol)

Vorschrift

A mixture of 5 g of ethyl nipecotate, 4.8 g of 4-chloropyridine hydrochloride, 6.6 g of triethylamine and 100 ml of xylene was stirred at 100° C. overnight. The reaction mixture was treated with ethyl acetate as the extracting solvent in an ordinary manner, and the obtained residue was purified by the silica gel chromatography (ethyl acetate/ethanol) to obtain the title compound.

Quelle