Reaktion #78207

Reaktionsgleichung

cyanogen bromide

methyl 3,4-diaminobenzoate

→

title compound

Methyl 2-aminobenzimidazole-5-carboxylate

Lösungsmittel

acetonitrile

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   workup.ADDITIONAqueous ammonia was added to the filtrate

Vorschrift

300 mg (1.8 mmol) of methyl 3,4-diaminobenzoate was stirred in 5 ml of water. 0.5 ml of a solution of 5 M of cyanogen bromide in acetonitrile was added to the obtained mixture, and they were stirred at room temperature for 20 minutes. The mixture was filtered. Aqueous ammonia was added to the filtrate. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the title compound was obtained.

Quelle