Reaktion #78179

Reaktionsgleichung

phthalic acid anhydride

4-methylpyrimidine

→

2-Pyrimidin-4-yl-indan-1,3-dione

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Waschenthe residue washed with methanol
3. 3
   Sonstigeby evaporating the filtrate

Vorschrift

7.87 g (53.1 mmol) phthalic acid anhydride and 22 ml (0.24 mol) 4-methylpyrimidine are stirred for 1 h at 140° C. and for 4 h at 21° C. The reaction mixture is then stirred with 15 ml methanol, filtered, and the residue washed with methanol. Further product is obtainable by evaporating the filtrate and stirring the residue with water: m.p.: 168-169° C.); Anal. calc.(C13H8N2O2) C, 69.64%; H, 3.60%; N, 12.49%. found C, 69.8%; H, 3.7%; N, 12.4%; FAB MS (M+H)+=225.

Quelle