Reaktion #7810

Reaktionsgleichung

2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole

NBS

benzoyl peroxide

→

2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole

Lösungsmittel

CCl4

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeCCl4 was removed in vacuo and residue
2. 2
   Sonstigewas purified by flash column (silica gel, hexanes:EtOAc 5:1)

Vorschrift

A solution of 2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole (200 mg, 0.74 mmol, 84%), NBS (179 mg, 0.81 mmol), and benzoyl peroxide (50 mg) in CCl4 (10 mL), was refluxed for 12 h. After cooling to rt, CCl4 was removed in vacuo and residue was purified by flash column (silica gel, hexanes:EtOAc 5:1) to afford 2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole. MS (ESI) 349 (M+H)+.

Quelle