Reaktion #78078

Reaktionsgleichung

water

5-bromo-2,4-dichloropyrimidine

4-methoxyphenol

potassium carbonate

→

product

Ausbeute 96.0%

5-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine

Ausbeute 96.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solid which separated out
2. 2
   Filtrationwas collected by filtration
3. 3
   Waschenwashed with water (50 ml)
4. 4
   Sonstigedried under high vacuum

Vorschrift

A mixture of 5-bromo-2,4-dichloropyrimidine (5.0 g, 22.0 mmol), 4-methoxyphenol (2.72 g, 22.0 mmol) and potassium carbonate (6.07 g, 44.0 mmol) in DMF (20 ml) was stirred for 24 hours. The mixture was added to water (100 ml) and the solid which separated out was collected by filtration, washed with water (50 ml) and dried under high vacuum to give the product (6.6 g, 96%). NMR: 3.8 (s, 3H), 7.0 (d, 2H), 7.2 (d, 2H), 8.8 (s, 11H).

Quelle