Reaktion #78061

Reaktionsgleichung

1-acetyl-4-aminopiperidine hydrochloride

4-fluorophenyl isocyanate

diisopropylethylamine

→

N-(1-acetylpiperidin-4-yl)-N′-(4-fluorophenyl)urea

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAn organic phase was separated
2. 2
   Extraktionan aqueous phase was extracted with dichloromethane
3. 3
   TrocknenA combined organic phase was dried over magnesium sulfate
4. 4
   Sonstigethe solvents were removed under reduced pressure
5. 5
   SonstigeAfter crystallization from diisopropyl ether and n-hexane

Vorschrift

To a suspension of 1-acetyl-4-aminopiperidine hydrochloride (536 mg) in dichloromethane (5 ml) were added 4-fluorophenyl isocyanate (375 μl) and diisopropylethylamine (575 μl ) at ambient temperature. After stirring for 3 hours, the reaction mixture was diluted with dichloromethane. An organic phase was separated and an aqueous phase was extracted with dichloromethane. A combined organic phase was dried over magnesium sulfate and the solvents were removed under reduced pressure. After crystallization from diisopropyl ether and n-hexane, N-(1-acetylpiperidin-4-yl)-N′-(4-fluorophenyl)urea (448 mg) was obtained.

Quelle