Reaktion #77986

Reaktionsgleichung

t-butyl 3-acetoxy-5-methyl-4-nitrophenylacetate

lithium hydroxide

ethyl acetate

sodium chloride

→

title compound

Ausbeute 104.2%

t-Butyl 3-hydroxy-5-methyl-4-nitrophenylacetate

Ausbeute 104.2%

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic layer was evaporated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in dichloromethane
3. 3
   SonstigeThis solution was dried
4. 4
   Sonstigeevaporated

Vorschrift

A solution of t-butyl 3-acetoxy-5-methyl-4-nitrophenylacetate (0.5 g, Reference Example 12) in methanol (6 mL) was treated with lithium hydroxide (0.2 g) in water (1.5 mL). After stirring for 2 hours the mixture was carefully acidified to pH 5 and then treated with ethyl acetate and sodium chloride. The organic layer was evaporated and the residue was dissolved in dichloromethane. This solution was dried and then evaporated to give the title compound (0.45 g) as a yellow green oil.

Quelle