Reaktion #77985

Reaktionsgleichung

t-butyl 3-hydroxy-5-methyl-4-nitrophenylacetate

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title compound

Ausbeute 91.1%

t-Butyl 4-amino-3-hydroxy-5-methyl-phenylacetate

Ausbeute 91.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter 4 hours the mixture was filtered through a pad of celite
2. 2
   Sonstigethe filtrate was evaporated

Vorschrift

A solution of t-butyl 3-hydroxy-5-methyl-4-nitrophenylacetate (0.47 g, Reference Example 11) in ethanol (25 mL) was treated with palladium on charcoal (approximately 0.08 g, 10%) and stirred under a hydrogen atmosphere. After 4 hours the mixture was filtered through a pad of celite and the filtrate was evaporated to give the title compound (0.38 g) as a green oil.

Quelle