Reaktion #77981

Reaktionsgleichung

3-hydroxy-4-nitrophenylacetic acid

ethanol

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title compound

Ethyl 3-hydroxy-4-nitrophenylacetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux temperature for 3 hours
3. 3
   Sonstigethen evaporated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in tert-butyl methylether
5. 5
   Waschenthe solution was washed with saturated aqueous sodium bicarbonate solution
6. 6
   Trocknenwith water, then dried
7. 7
   Sonstigeevaporated

Vorschrift

A solution of 3-hydroxy-4-nitrophenylacetic acid (4.0 g, prepared according to the procedure described by Meyer et al, J.Med.Chem., 1997, 40, pages 1049-1062) in ethanol (approximately 100 mL) was treated with concentrated hydrochloric acid (5-8 drops) was heated at reflux temperature for 3 hours then evaporated. The residue was dissolved in tert-butyl methylether and the solution was washed with saturated aqueous sodium bicarbonate solution, then with water, then dried, and then evaporated to give the title compound (5.0 g) as a light yellow solid.

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