Reaktion #77980

Reaktionsgleichung

ethyl 3-hydroxy-4-nitrophenylacetate

ammonium formate

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title compound

Ausbeute 76.1%

Ethyl 4-amino-3-hydroxy-phenylacetate

Ausbeute 76.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter 30 minutes the mixture was filtered hot through a pad of celite
2. 2
   Einengenthe filtrate was concentrated

Vorschrift

A solution of ethyl 3-hydroxy-4-nitrophenylacetate (5.0 g, Reference Example 4) was dissolved in ethanol (approximately 200 mL) was treated with ammonium formate (approximately 20 g). The mixture was warmed to 50° C. and then treated cautiously with palladium on charcoal (approximately 1 g, 5%)—effervescence was observed. After 30 minutes the mixture was filtered hot through a pad of celite and the filtrate was concentrated to give the title compound (3.3 g) as a black solid.

Quelle