Reaktion #77970

Reaktionsgleichung

2-phenylbenzimidazole

DBU

→

1-methyl-2-phenylbenzimidazole

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturthe resulting mixture was heated
3. 3
   SonstigeThe solvent was evaporated under vacuum
4. 4
   workup.DISSOLUTIONthe resulting oil was dissolved in methylene chloride (2 mL)
5. 5
   Filtrationfiltered through silica gel (2:1 EtOA/hexane)
6. 6
   SonstigeThe solvent was evaporated under vacuum

Vorschrift

To a mixture of 2-phenylbenzimidazole (1.02 g, 5.25 mmol) in DMC (10 mL), DBU (0.80 g, 5.25 mmol) was added and the resulting mixture was heated to reflux (90° C.) for 6 hours. The solvent was evaporated under vacuum and the resulting oil was dissolved in methylene chloride (2 mL) and filtered through silica gel (2:1 EtOA/hexane). The solvent was evaporated under vacuum to afford 1-methyl-2-phenylbenzimidazole as a solid. The yield of 1-methyl-2-phenylbenzimiazole as determined by HPLC analysis was 98%.

Quelle