Reaktion #77960

Reaktionsgleichung

tert-butyl nitrite

dimethyl disulfide

4-bromo-3-methyl-2-methylthioaniline

dimethyl disulfide

→

2-methyl-3,4-dimethylthiobromobenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationFor work-up, the solid is filtered off with suction
2. 2
   workup.ADDITIONthe filtrate is diluted with methylene chloride
3. 3
   Extraktionextracted with dilute hydrochloric acid
4. 4
   WaschenThe organic phase is washed with saturated aqueous NaHCO3 solution
5. 5
   Trocknendried over sodium sulfate
6. 6
   Filtrationfiltered off
7. 7
   Einengenconcentrated
8. 8
   SonstigeExcess dimethyl disulfide is removed under oil pump vacuum

Vorschrift

14.8 g (129 mmol) of tert-butyl nitrite and 20 g of copper powder are initially charged in 50 ml of dimethyl disulfide, and a solution of 20 g (86 mol) of 4-bromo-3-methyl-2-methylthioaniline in 100 ml of dimethyl disulfide is added dropwise at from 50 to 55° C. The mixture is subsequently stirred at 50° C. for 4 hours. For work-up, the solid is filtered off with suction and the filtrate is diluted with methylene chloride and extracted with dilute hydrochloric acid. The organic phase is washed with saturated aqueous NaHCO3 solution, dried over sodium sulfate, filtered off and concentrated. Excess dimethyl disulfide is removed under oil pump vacuum.

Quelle