Reaktion #77945

Reaktionsgleichung

2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline

dimethyl sulfide

n-butyl nitrite

→

3-(2-methyl-6-methylthiophenyl)-4,5-dihydroisoxazole

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenFor work-up, the mixture is then washed with dilute hydrochloric acid and water
2. 2
   Einengenconcentrated under reduced pressure
3. 3
   SonstigeThe product can be purified further by trituration in methyl tert-butyl ether

Vorschrift

40 g (0.22 mol) of 2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline and 0.44 g of copper(I) chloride are initially charged in 300 ml of dimethyl sulfide, and 26.1 g of n-butyl nitrite (0.23 mol) are added dropwise at 55-66° C. The mixture is then stirred at 60° C. for 1.5 hours. For work-up, the mixture is then washed with dilute hydrochloric acid and water and then concentrated under reduced pressure. This gives 38.7 g (85%) of a dark oil which solidifies after a while (content according to HPLC 94%). The product can be purified further by trituration in methyl tert-butyl ether.

Quelle