Reaktion #77933

Reaktionsgleichung

sodium hydroxide

acrylonitrile

ortho-nitrotoluene

→

acrylonitrile

4-(2-nitro-phenyl)butyronitrile

Ausbeute 40.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturreflux condenser
2. 2
   workup.ADDITIONis added dropwise
3. 3
   Temperaturmaintained at this temperature for 3 h
4. 4
   SonstigeThe phases are separated
5. 5
   Sonstigethe organic phase is dried
6. 6
   Filtrationfiltered off

Vorschrift

0.75 ml of 45% sodium hydroxide solution and 175 mg of tributylmethylammonium chloride are placed in a 100 ml three-neck flask with a dropping funnel, reflux condenser and internal thermometer, stirring. At 40° C., a mixture of 1.4 ml acrylonitrile (21.15 mmol) and 25 ml ortho-nitrotoluene is added dropwise and maintained at this temperature for 3 h. The phases are separated, and the organic phase is dried and filtered off. With quantitative conversion of acrylonitrile, 1.61 g of 4-(2-nitro-phenyl)butyronitrile (8.5 mmol, 40%) are obtained.

Quelle